Subsystem: Histidine Biosynthesis

Ross Overbeek, Fellowship for Interpretation of Genomes


Functional Roles
Abbrev Functional Role
hisG ATP phosphoribosyltransferase (EC 2.4.2.17)
hisE Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
hisI Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)
hisA Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
hisH Imidazole glycerol phosphate synthase subunit hisH (EC 2.4.2.-)
hisF Imidazole glycerol phosphate synthase subunit hisF (EC 4.1.3.-)
hisB Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
hisC Histidinol-phosphate aminotransferase (EC 2.6.1.9)
hisK Histidinol-phosphatase (EC 3.1.3.15)
hisK2 Histidinol-phosphatase [alternative form] (EC 3.1.3.15)
hisD Histidinol dehydrogenase (EC 1.1.1.23)



Basic Spreadsheet
Organism hisG hisE hisI hisA hisH hisF hisB hisC hisK hisK2 hisD
Sulfolobus solfataricus P2 [A] 538 543 545 539 544 541 540 537 542
Corynebacterium glutamicum ATCC 13032 [B] 1447 1448 2012 2015 2016 2013 2019 2020 2014, 765 2021
Mycobacterium bovis AF2122/97 [B] 2124 2125 1615 1612 1611 1614 1610 1609 3136, 1613 1608
Mycobacterium tuberculosis CDC1551 [B] 2241 2242 1687 1684 1683 1686 1682 1681 3341, 1685 1680
Kineococcus radiotolerans SRS30216 [B] 2278 2277 2284 2458 2457 2282 2456 2455 2008 2450
Streptomyces avermitilis MA-4680 [B] 6909 6908 6172 6160 6159 6162 6157 6156 3052 6155
Propionibacterium acnes KPA171202 [B] 1402 1403 1109 1140 1139 1362 1138 1137 1254 1136
Bifidobacterium longum DJO10A [B] 126 125 191 554 555 192 557 558 559
Aquifex aeolicus VF5 [B] 1123 1364 1364 907 518 142 30 1441 552
Bacteroides fragilis NCTC9343 [B] 1261 2709 2709 2707 2706 2708 1258 1259 1258 1260
Organism Variant Code hisG hisE hisI hisA hisH hisF hisB hisC hisK hisK2 hisD
Cytophaga hutchinsonii [B] 261 590 590 1114 1115 1112 1116 1117 1116 260
Bacillus subtilis subsp. subtilis str. 168 [B] 3498 3492 3492 3494 3495 3493 3496 2266 2965 3497
Oceanobacillus iheyensis HTE831 [B] 555 549 549 551 552 550 553 548 557 554
Staphylococcus aureus subsp. aureus MW2 [B] 2598 2591 2591 2593 2594 2592 2595 2596 2597
Staphylococcus epidermidis ATCC 12228 [B] 271 277 277 275 274 276 273 504 272
Chromobacterium violaceum ATCC 12472 [B] 610 621 620 617 616 618 614 613 611
Buchnera aphidicola str. APS (Acyrthosiphon pisum) [B] 100 107 107 105 104 106 103 102 103 101
Escherichia coli K12 [B] 1994 2001 2001 1999 1998 2000 1997 1996 1997 1995