A 3-gene Cluster Containing a cell envelope protein, a protein kinase, and a phosphotransferase

This cluster contains at least three genes worth noting:

  1. The red genes numbered 1 are, according to Gary Olsen, ATPase YjeE, predicted to have essential role in cell wall biosynthesis / COG3178: Predicted phosphotransferase related to Ser/Thr protein kinases.
  2. The green genes numbered 2 seem to be a Nucleotidyltransferase family protein.
  3. The blue genes numbered 3 are annotated as Organic solvent tolerance protein precursor.


Thus, we have a cluster relating to cell wall biosynthesis, perhaps. It occurs in a number of spots throughout the Proteobacteria. Note the occurrences of surA (numbered 4), which is believed to be a periplasmic molecular chaperone protein facilitating correct folding and maturation of outer membrane proteins in Gram-negative bacteria.